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Semaglutide reduces appetite, slows digestion, improves blood sugar control, Semaglutide is the active pharmaceutical ingredient (API) in FDA-approved Ozempic® and Wegovy®. Compounded semaglutide is not FDA-approved, is not the same as these brand-name products, and has not been reviewed by the FDA for safety or effectiveness.
FDA registration trials for brand-name GLP-1 medications showed average weight loss of 10–15% of body weight over 68 weeks. Compounded versions are not FDA-approved and have not undergone clinical trials. Individual outcomes vary.
Semaglutide targets one receptor (GLP-1), while tirzepatide targets two (GIP + GLP-1). Tirzepatide produces slightly greater average weight loss (20-22% vs 10-15%), but both medications work through similar mechanisms. Your provider can help determine which is appropriate for your needs.
Compounded semaglutide is a preparation made by a licensed compounding pharmacy that contains semaglutide as the active pharmaceutical ingredient (API). Ozempic® and Wegovy® are FDA-approved brand-name medications that also contain semaglutide as their API. Compounded semaglutide is not FDA-approved, has not undergone FDA review for safety or effectiveness, and is not the same as, nor equivalent to, Ozempic® or Wegovy®. It is prepared on a per-patient basis by a licensed pharmacy under a valid prescription.